عنوان مقاله [English]
نویسنده [English]چکیده [English]
The aim of this study was to evaluate the preventive effects of Jujube (Ziziphus jujuba) extract on fatty liver disease induced by high fat diet in the rats. For this purpose, 80 male Wistar rats were randomly divided to 4 equal groups including: 1-Healthy control, 2-Feeding with high fat diet, 3-Feeding with high fat diet plus Clofibrate (320 mg/kg) treatment and 4- Feeding with high fat diet and treated with Jujube extract (200 mg/kg). Steatosis created by high fat emulsion (10 ml/kg). Different experimental groups compared considering serum biomarkers of liver tissue injury, hepatic antioxidant activity and liver histopathological changes. In the rats fed with high-fat diet, serum levels of hepatocellular enzymes significantly (P<0.01) reduced and liver antioxidants activities significantly (P<0.01) increased compared to control group. In extract treatment group, elevated markers of liver tissue injury and Malondialdehyde significantly reduced and declined serum albumin and protein significantly (P<0.01) increased. Also, in this group, Jujube treatment significantly (P<0.01) improved the activities of liver antioxidants and significantly (P<0.01) decreased liver Malondialdehyde levels. Histopathology of the liver confirmed the biochemical changes. The results showed Jujube extract exerts protective effects against hepatic steatosis in rats fed with high fat diet possibly through increasing of antioxidant activities.