عنوان مقاله [English]
For this purpose, 360 Zebra fish were divided into two groups and fed for 60 days with commercial food (control group) or enriched diet with Lactobacillus fermentum as probiotic (test group). After this time, both groups were in the vicinity of 0.3 mg / l of lead and their survivability, tissue metal uptake and their histological damages were studied within 48 hours. Based on the results, the fish in the test group were able to tolerate the lethal dose of lead for more than 24 hours compared to the control group. After 48 hours of poisoning, the amount of metal uptake in both liver and gill tissue was significantly lower for the experimental group than in the control group. Moreover, tissue damage such as vein dilatation, lamella fusion and telangiectasia were significantly lower in the experimental group than the control group. Epithelial cell hyperplasia was not observed in the probiotic- treated group. It could be concluded that probiotic enriched diet can significantly reduce the toxic effects of lethal doses of lead in fish.