عنوان مقاله [English]
Ketamine is a suitable injectable anesthetic in human and animal that has a low intestinal
absorption rate. It's bioavailability in human with oral administration is %207 and with rectal
administration in cat is %43.56.1 .this drug has some side effects such as hypertension,
histamine releasing effects , hallucination , hyper salivation (specially with oral administration)
and etc. Midazolam is a short acting benzodiazepine that can pass trough blood-brain barrier and
causes CNS suppression. Then it seems that co administration of Midazolam and ketamine
cause more effective & deep CNS depression effects.
The aim of this study was evaluation of ketamine and Midazolam CNS suppression effects in
the manner of single and together in cat. Ten free roaming male & mature cats received drugs
[ketamine (20, 40, 80mg/kg) & Midazolam (0.3, 0.6, 1.2mg/kg)] first in mixture of milk (40ml)
or meat (30g) or sublingual spray rout. In 2nd stage they received concomitant doses of
Midazolam & ketamine by the method mentioned above. Each animal was observed continually
by educated observer for CNS depression as graded on the behavioral scales.
Almost all of the animals rejected receiving drugs in mixture of milk and meat. So subligual
spray rout used for oral administration of drugs. Ketamine & Midazolam showed a dose
dependent effect in different administered doses. Concomitant use of Midazolam with ketamine
improved ketamine's CNS depression effects. Also duration of CNS depression was longer with
co administration of these two drugs. Results showed that administration of ketamine &
Midazolam in mixture of milk & meat is not a suitable method in cats. But a strong and long
time CNS depression is achieved when ketamine sprayed in mouth (as sublingual form).