عنوان مقاله [English]
نویسندگان [English]چکیده [English]
Nowadays, especially opportunistic fungi such as Candida albicans are the most common risk
factors in patients who are immunocompromised. Fungal infections caused by Candida species
and increasing strains resistant to azole drugs in Immunosuppression patients are important to
enjoy. The toxicity of drugs used, the resistance of the fungus and problems from drug
interactions, necessitates the use of more effective and less toxic drugs cause the screw.
Pomegranate consumption except for nutrition is impressive for medicinal and therapeutic
effects. The aim of this study was to investigate the effect of pomegranate peel extract at doses
concentrations of 25, 50, 100 and 200 mg/kg on growth of C. albicans (ATCC 10231) in
alloxan-induced diabetic rat. The animals were made diabetic by intraperitoneal injection of
alloxan (150 mg/kg). After diabetes induction, they were infected by Candida albicans, orally.
Then, treatments of extract and Itraconazole were done orally. Sampling of fungus from month,
culturing and colony counting were done daily for evaluating effects of extract and Itraconazole
on fungal growth. The results showed that oral treatment of hydro-alcoholic peel extract
improved Candida albicans infections in diabetic rats. Its potency is similar to Itraconazole, as
synthetic drug. On the second day of treatment, significant effect of extract on growth C.
albicans was shown (P<0.001). Comparison between effects of pomegranate extract and
Itraconazole on C. albicans was significant. The results suggest antifungal effect extract of
pomegranate compared with the antifungal medication. As a result, consumption of
pomegranate extract inhibited the growth of Candida albicans in the diabetic rats.