نوع مقاله: مقاله پژوهشی
نویسندگان
1 دانشجوی دامپزشکی، دانشکده دامپزشکی، واحد علوم و تحقیقات تهران، دانشگاه آزاد اسلامی، تهران، ایران
2 گروه فاماکولوژی، دانشکده دامپزشکی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران
3 گروه فارماکولوژی، دانشکده دامپزشکی، دانشگاه تهران، ایران
چکیده
کلیدواژه‌ها
عنوان مقاله [English]
نویسندگان [English]
Tendency to utilize Ephedra containing products is increasing due to their favorable properties
such as weight loos, antibacterial, antisensetive etc. Due to the presence of gastro-intestinal
system agonism α and β adrenergic compound and lack of systematic research on this issue, we
conducted to determine effects of the hydroethanolic extract of Ephedra major (E. Major) host
on jejunum. Isolated jejunum from male Wistar rat were tested in the organ bath. Rats were
anesthetized and the jejunum was isolated and placed in Krebs solution. Then, it was cut into
segment of 1.5-2 cm and mounted in 25 ml chambers of organ bath. E. Major extract had a
relaxation effect on rat jejunum. According to the results, the cumulative concentration of E.
Major (0.00625 - 3 mg/ml) relaxed the KCl (80 Mm) - and acetylcholine (0.1 Mm) - induced
contraction dose-dependently (P≤0.05). The inhibitory effect of extract on contraction induced
by KCl was unaffected by phenoxybenzamine (0.001 Mm). But verapamil (0.001 Mm) and
propranolol (0.001 Mm) inhibited the relaxant effect (P≤0.05). The inhibitory effect of extract
on contraction induced by acetylcholine had synergism effect by verapamil, phenoxybenzamine
and propranolol (P≤0.05). These findings revealed that β-adrenergic receptors and presumably
other channels such as Ca2+ channels involves in inhibitory effect of E. Major extract. The
results support the possible beneficiary effects of this plant in traditional medicine.
کلیدواژه‌ها [English]
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