عنوان مقاله [English]
Diarrhoea is one of the most important GI tract that reduces meaningful performance of the
patient. Dried whole plant parts of Ludwigia hyssopifolia were subjected to successive cold
extraction with n-hexane, ethylacetate and methanol. The methanol extract (LHM), obtained as
1% yield, showed significant antidiarrheal property by reducing diarrheal episodes in castor oil
and serotonin induced diarrhea in laboratory mice at a dose of higher than 100mg/kg body
weight as compared to standard drug loperamide given at a dose of 66.67 μg/kg body weight.
The percent reduction in diarrheal episode by 56.32 and 89.66 after castor oil challenge and
59.09 and 86.36 in serotonin induced diarrhea was observed at doses of 200mg/kg and
400mg/kg body weight of the extract respectively. The extract LHM was also found to reduce
the gastrointestinal motility by 53.8% at a dose of 100mg/kg body weight as compared to
control, while no remarkable inhibition of gastrointestinal motility was seen at a dose of
50mg/kg body weight of the extract.