عنوان مقاله [English]
نویسندگان [English]چکیده [English]
Xylazine is preanesthetic drug that have nausea and vomiting effects. This study was done in
order to assessment of the effects of dexamethasone, metoclopramide and the combination of
dexamethasone - metoclopramide administrations in prophylaxis of nausea and vomiting after
xylazine administration in dogs.
15 mixed breed dogs with average weight 18.9±5 Kg were randomly selected in 3 groups
including intravenous (I.V) dexamethasone 1mg/kg , I.V metoclopramide 0.5
mg/kg and combination of dexamethasone - metoclopramide (0.5 -1 mg/kg). For induction of anesthesia in
all groups, initially I.V diazepam (0.2 mg/kg) then I.V xylazine ( 2 mg/kg) and I.V morphine (2
mg/kg) were administrated and dexamethasone, metoclopramide and combination of
dexamethasone-metoclopramide were injected and dogs were underwent the laparotomy
technique. Anesthetic and recovery times, also nausea and vomiting effects at 30 min, 2, 4, 8
and 24 h after anesthesia were recorded and results were analyzed by ANOVA and (P < 0.05)
were considered significant.
Duration of anesthesia at dexamethasone group were 48.2±2.8 min, metoclopramide group
51.7±2.3 min and in dexamethasone-metoclopramide group 45.7±2.3 min, respectively.
Significant difference was not seen at duration of anesthesia between three groups (P> 0.05)
none was seen nausea and vomiting.
Single or co-administration of dexamethasone and metoclopramide prevents nausea and
vomiting in operation and recovery period.